대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.410.2-411
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- 2002
Ketoprofen-Polyethylene Glycol Conjugate: Pharmacokinetics. anti-inflammatory and analgesic activity
- Jang, Mi-Hee (College of Pharmacy, Sookmyung Womens University) ;
- Kim, Soo-Yeon (College of Pharmacy, Duksung Womens University) ;
- Jeong, Choon-Sik (College of Pharmacy, Duksung Womens University) ;
- Oh, Seaung-Youl (College of Pharmacy, Duksung Womens University)
- 발행 : 2002.10.01
초록
Ketoprofen (KP), a potent analgesic and non-steroidal anti-inflammatory drug, has some disadvantages such as gastro-intestinal irritation. short half-life (1.5-4 hour) in plasma and low solubility in aqueous solution. In order to minimize these disadvantages. we have recently prepared a KP prodrug, KP-polyethylene glycol conjugate (KPEG750, PEG Mw=750), and investigated its pharmacokinetic behavior. anti-inflammatory and analgesic effect. (omitted)
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