Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Solid Lipid Nanoparticles(SLN) as Controlled Release Subcutaneous Injections of Local Anesthetics

  • Park, Yong-Keun (College of Pharmacy, Chungnam National University) ;
  • Lee, Jong-Hwa (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Kim, Dong-Woo (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Yoon, Jae-Nam (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Jun, Il-Soon (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Lee, Eun-Mi (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Lee, Gye-Won (Dep. of Pharmaceutical Engineering Konyang University) ;
  • Jee, Ung-Kil (Dep. of Pharmaceutical Engineering Konyang University)
  • Published : 2002.10.01
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Abstract

Local anesthetics are used to reduce pain. but they are so frequently injected to patients. So we prepared lidocaine solid lipid nanopaticles for long acting subcutaneous injection to decrease the number of times of injection. Solid lipid nanoparticles were prepared by spray drying method. First. drug. lipid. plasticizer and surfactant were dissolved in methylene chloride. and we operated spray dryer using this solution at setting value. (omitted)

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