Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Enantiomeric Profiling Analysis of NSAIDs by Capillary Electrophoresis Using TM $\beta$-Cyclodextrin as the Chiral Selector

  • Kim, Ji-Young (Dept. of Biotechnology ＆ Bioproduct Research Center, Yonsei Univ.) ;
  • La, Sookie (College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Jung-Han (Dept. of Biotechnology ＆ Bioproduct Research Center, Yonsei Univ) ;
  • Kim, Kyoung-Rae (Dept. of Biotechnology ＆ Bioproduct Research Center, Yonsei Univ.)
  • Published : 2002.10.01
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Abstract

Because of the differences in pharmacological properties between enantiomers of chiral acidic non-steroidal antiinflammatory drugs (NSAIDs) in human body. accurate determinations of their optical purities have been in great need. An efficient capillary electrophoretic (CE) profiling method was developed for the enantioseparation of NSAIDs. Capillary electrophoretic conditions were optimized using TM$\beta$-cyclodextrin as the chiral selectors under MES buffer. (omitted)

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