Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Isolation of inhibitors of NF-$\kappa$B activation by UV stimuli in transfectant HaCaT cells from Acanthopanacis sessilifflorum

  • Kim, Seong-Kie (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University) ;
  • Kim, Yeong-Shik (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University) ;
  • Ahn, Kwang-Seok (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University) ;
  • Heor, Jung-Hee (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University) ;
  • Kim, Young-Sup (Korea Research Institute of Chemical Technology, Natural Products research institute, Seoul National University)
  • Published : 2002.10.01
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Abstract

Nuclear-kappa B(NF-$\kappa$B) plays a role in the regulation of genes responsible for inflammatory and immune responses as well as growth control of cells. A cell-based assay system for guiding NF-KB activity was developed to determine the influence of activated NF-KB in human keratinocytes. It suggested that this system could be used to determine the quantitative measurement of NF-$\kappa$B activity in the human skin and allow the monitoring of anti-inflammatory agent for dermatological means from various environmental stimuli. (omitted)

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