Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Anti-complement Activity of Flavonoids from Litsea japonica

  • Lee, Sun-Young (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Min , Byung-Sun (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Kim, Jung-Hee (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Moon, Hyung-In (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Lee, Joong-Ku (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Kim, Tae-Jin (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University. Daejeon 305-764) ;
  • Lee, Hyeong-Kyu (College of Pharmacy, Chungnam National University. Daejeon 305-764)
  • Published : 2002.10.01
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Abstract

AIzelin (1) and quercitrin (2) isolated from the EtOAc-soluble fraction of the leaves of Litsea japonica Jussieu (Lauraceae) showed inhibitory activity against classical pathway complement system with 50% inhibitory concentration ($IC_{50}$/) values of 112.2 and 198.2 $\mu\textrm{g}$/$m\ell$. respectively. For the structure-activity relationship of flavonoids on anti-complement system. myricitrin (3) from JUQ/ans mandshurica Maximowicz (Juglandaceae) also tested anti-complement activity. while this was devoid of any significant activity. (omitted)

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