Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.364.1-364.1
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- 2002
DESIGN AND SYNTHESIS OF A3 ADENOSINE RECEPTOR LlGANDS. 3′-FLUORO ANALOGUES OF CI- IB-MECA
- Lim, Moo-Hong (College of Pharmacy. Ewha Womans University) ;
- Kim, Hea-Ok (Division of Chemistry and Molecular Engineering. SN) ;
- Moon, Hyung-Ayong (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University) ;
- Jeong, Lak-Shin (College of Pharmacy, Seoul National University)
- Published : 2002.10.01
Abstract
2-Chloro-N6-(3-iodobenzyl)-adenosine-5'-methylcarboxamide (2-CI-IB-MECA) has been recognized to be one of the most selective agonists (Ki = 1.0 nM) for rat adenosine A3 receptor. On the basis of the high binding affinity of 2-CI-IB-MECA to adenosine A3 receptor. it was interesting to find out whether 2'- and/or 3'-hydroxyl group of 2-CI-IB-MECA is essential for the binding affinity to the receptor. (omitted)
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