Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.362.1-362.1
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- 2002
Stereocontrolled asymmetric synthesis of pancratistatin
- Park, Je-Eun (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
- Kim, Sang-Hee (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
- Ko , Hyo-Jin (Natural Products Research Institute, College of Pharmacy, Seoul National University)
- Published : 2002.10.01
Abstract
Pancratistatin is a highly oxygenated phenanthridone alkaloid. exhibits a high level of in vitro and in vivo cancer cell growth in inhibitory activity. and antiviral activity. The asymmetric synthesis of this alkaloid has been. accomplished from the commercially available (R)-(＋)-3-Butyn-2-ol. We utilized the Claisen rearrangment and metathesis to install stereogenic centers in the cyclohexene ring that has absolute chemistry. (omitted)
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