Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Anti-angiogenic and anti-tumor activity of 2′ -hYdroxy-4′ -methoxychalcone

  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Lim, Soon-Sung (Natural Products Research Institute, Seoul National University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • Published : 2002.10.01
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Abstract

In the previous study, we reported that 2'-hydroxy-4'-methxoychalcone, synthetic chalcone inhibited PGE2 production in TPA- stimulated rat peritoneal macrophages by inhibiting the induction of COX-2 protein. The present study was carried out to clarify whether 2'-hydroxy-4'-methoxychalcone inhibit angiogenesis by the experimental methods in vitro and in vivo. 2'-Hydroxy-4'-methoxychalcone decreased angiogenesis of both chick embryos in the chorioallantoic membrane assay and basic fibroblast growth factor-induced vessel formation inthe mouse Martigel plug assay. (omitted)

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