Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.359.1-359.1
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- 2002
Effect of DNA methylation on the reactivity of DNA alkylating agents
- Yoo, Ja-Kyung (Sungkyunkwan University) ;
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Park, Hyun-Ju
(Sungkyunkwan University)
- Published : 2002.10.01
Abstract
In mammalian species, CpG dinucleotides are highly methylated with 60-90% methylation at the 5-position of cytosine. The pattern of DNA methylation in a cell dramatically affects the function of the DNA by switching genes on or off. Abnormal methylation events occur during aging and in the development of many cancers. Methylated CpG was reported recently to affect the reactivity of agents (mitomycin C and benzo ［a］pyrenediolepoxide) that can fromguanine adducts in DNA. (omitted)
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