대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.357.2-357.2
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- 2002
Synthesis and in vitro/in vivo properties of prednisolone 21-sulfate sodium as a colon-specific prodrug of prednisolone
- Doh, Min-Ju (College of pharmacy. Pusan National University, Pusan 609-735,Korea) ;
- Kim, In-Ho (College of pharmacy. Pusan National University, Pusan 609-735,Korea) ;
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Jung, Yun-Jin
(College of pharmacy. Pusan National University, Pusan 609-735,Korea)
;
- Kong, Hye-Sik (College of pharmacy. Pusan National University, Pusan 609-735,Korea) ;
- Kim, Young-Mi (College of pharmacy. Pusan National University, Pusan 609-735,Korea)
- 발행 : 2002.10.01
초록
Corticosteroids have been used most frequently for inflammatory bowel disease.They are well absorbed and only a limited fraction of the dose is delivered to the inflammatory site in the colon. To reduce side effects by the systemic absorption. cOlon-specific delivery is highly desirable. We prepared prednisolone 21-sulfate sodium (PDS) and investigated its suitability as a colon-specific prodrug of prednisolone(PD). (omitted)
키워드