Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.356.1-356.1
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- 2002
Synthesis of Novel Dimethylcyclopropyl Nucleosides as Potential Antiviral Agents
- Kook, Min-Cheol (College of Pharmacy. Chonnam National University) ;
- Park, Jae-Kyung (College of Pharmacy. Chonnam National University) ;
- Cho, Ae-Hee (College of Pharmacy. Chonnam National University) ;
- Choi, Bo-Gil (College of Pharmacy. Chonnam National University)
- Published : 2002.10.01
Abstract
The carbocyclic nucleosides have extensively studied as a promising antiviral agents having chemical and metabolical stability. In our research program for discovery of antiviral drugs. some novel dimethylcyclopropyl nucleosides possessing additional methyl spacer between purine bases and the ring was synthesized. The important intermediate, dimethylcyclopropyl alcohol was synthesized from ethyl chrysanthemate via its ozonolysis, isomerization reduction. (omitted)
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