대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.353.3-354
- /
- 2002
Synthesis of N-arylalkylbenzimidazolones(thiones) and 3-arylalkyl-3,4-dihydro-1 H-Quinazolinones(thinones) as conform atonally restricted PETT analogs for inhibition of HIV-1 reverse transcriptase
- Lee, Jee-Hyun (College of Pharmacy. Chungnam National University) ;
- Cho, Soo-Hyun (Korea research Institute of Chemical Technology) ;
- Dang, The-Hung (Korea research Institute of Chemical Technology) ;
-
Lee, Chong-Kyo
(Korea research Institute of Chemical Technology)
;
-
Kim, Hae-Soo
(Korea research Institute of Chemical Technology)
;
- Jung, Sang-Hun (Korea research Institute of Chemical Technology)
- 발행 : 2002.10.01
초록
The reverse transriptase (RT) of HIV-1 is a proven target for inhibition of HIV-1 replication. Many nonnucleoside RT inhibitors (NNRTls) are in development stage for the clinical use: Among them. trovirdine (PETT). (thiophene) ethylpyridylthioureas (TET). and phenylethylpyridylureas (urea-PETT) are simple and flexible arylalkylarylureas. These are now considered to be very important as a potential therapeutics with remarkable antiviral activity against various mutant strains. (omitted)
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