대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.345.3-346
- /
- 2002
Diastereoselective Synthesis of (＋)-Frontalin
- Jung, Jung-Hwa (College of Pharmacy. Sookmyung Women′s University) ;
- Kim, Hee-Doo (College of Pharmacy. Sookmyung Women′s University)
- 발행 : 2002.10.01
초록
In connection with the asymmetric synthesis of chiral l.2-diol. we report here the total synthesis of (＋)-frontalin using diastereoselective alkylation featuring tridentate chelation-controlled asymmetric alkylation of a-hydroxyketone, in which the chiral auxiliary is attached to the hydroxyl group as ether linkage. The starting D-glyceraldehyde acetonide was converted (S)- ［(4R)-2.2-dimethyH,3-dioxolan-4-yl］ (4-methoxyphenyl) methanol. (omitted)
키워드