대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.338.1-338.1
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- 2002
A new strategy for high productivity of Erythropoietin in CHO cell by introducing urea cycle enzymes
- Lee, Yun-Jeong (College of Pharmacy. Chung-Ang University) ;
- Chang, Kern-Hee (Samsung Fine Chemicals Co., LTD R＆D center) ;
- Kim, Jung-Hoe (Dept. of Biological Sciences, KAIST) ;
- Kim, Hong-Jin (College of Pharmacy. Chung-Ang University)
- 발행 : 2002.10.01
초록
The efficient Erythropoietin(EPO)-expression system in mammalian cells is required for massive production for therapeutic use. Ammonium ion is a major problem in the production of useful proteins by cultured animal cells and therefore it is of importance to devise a system by which a high productivity of human therapeutic recombinant protein can be maintained or enhanced under low ammonium concentration. (omitted)
키워드