Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Decusinol angelate inhibits UVB-induced MMP-l induction via Mitogen-activated Protein Kinase Pathway in human skin fibroblasts

  • Wang, Hye-Sung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
  • Kang, Sun-Myung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
  • Cho, Hong-Yon (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
  • Ho, Jin-Nyung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
  • Kim, Ik-Hwan (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University)
  • Published : 2002.10.01
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Abstract

UV-B irradiation increases the synthesis of matrixmetalloproteinase-1 (MMP-1) that degrades skin collagen in human skin. In this work, we investigated the photoprotective effect of decursinol angelate (DEA) extracted Irom Angelica gigas on human skin libroblasts. DEA inhibited UVB-induced MMP-1 induction, which was conlirmed by western blot and ELISA. We examined upstream signal transduction pathway and the action mechanism of DEA on UVB induction of MMp in human skin fibroblasts. (omitted)

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