Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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REGULATION OF BETA-AMYLOID-STIMULATED PROINFLAMMATORY RESPONSES VIA MITOGEN ACTIVATED PROTEIN KINASES AND REDOX SENSITIVE TRANSCRIPTION FACTORS

  • Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
  • Published : 2002.10.01
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Abstract

Inflammatory as well as oxidative tissue damage has been associated with pathophysiology of Alzheimer's disease (AD), and nonsteroidal anti-inflammatory drugs have been shown to retard the progress of AD. In this study, we have investigated the molecular mechanisms underlying oxidative and inflammatory cell death induced by beta-amyloid (Abeta), a neurotoxic peptide associated with senile plaques formed in the brains of patients with AD, in cultured PC12 cells. (omitted)

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