Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.325.2-325.2
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- 2002
Involvement of G1 arrest and caspase-3 activation in apoptosis induced by bovine lactoferricin
- Yoo, Yung-Choon (Department of Microbiology) ;
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Lee, Kyung-Bok
(Department of Biochemistry, College of Medicine, Konyang University)
- Published : 2002.10.01
Abstract
We investigated the effect of bovine lactoferricin (Lfcin-B) on cell cycle regulation and caspase activation in tumor cells. Treatment with Lfcin-B resulted in the production of intracellular reactive oxygen species (ROS) during apoptosis of THP-1 cells. Biochemical analysis revealed that Lfcin-B-induced apoptosis. the cell cycle arrest and caspase activation were completely abrogated by addition of an antioxidant such as N-acetylcysteine(NAC). (omitted)
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