Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.319.2-319.2
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- 2002
Effects of chitosan on the decreased renal dipeptidase release by nitric oxide from renal proximal tubules
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Yoon, Hyun-Joong
(College of Pharmacy. Chonnam National University)
;
- Park, Eun-Mi (College of Pharmacy. Chonnam National University) ;
- Park, Haeng-Soon (College of Pharmacy. Chonnam National University)
- Published : 2002.10.01
Abstract
Chitin is a major component of the shells of crustacea such as crab. shrimp and crawfish. Renal dipeptidase (RDPase. EC 3.4.13.19), an ectoenzyme of renal proximal tubules. is covalently bound to outer leaflet of lipid bilayer via glycosylphosphatidylinositol (GPI)-anchor. The biological role of RDPase was suggested as the hydrolysis of dipeptide into free-amino acids before renal reabsorption. The underlying biochemical mechanism of decreased RDPase release was suggested as nitric oxide (NO) production. (omitted)
Keywords