Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Peroxynitrite Scavenging Activity of Active Constituents from Scutellaria baicalensis

  • Kim, Dae-Hyun (College of Pharmacy, Pusan National University) ;
  • Choi, Jae-Sue (Faculty of Food Science and Biotechnology, Pykyong National University) ;
  • Jung, Hyun-Ah (Faculty of Food Science and Biotechnology, Pykyong National University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee Unviersit) ;
  • Chung, Hae-Young (College of Pharmacy, Pusan National University)
  • Published : 2002.10.01
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Abstract

Peroxynitrite, formed from the reaction of .O2- and .NO, is a cytotoxic species that can oxidize several cellular components such as proteins. lipids and DNA. Oxidative stress is considered to be the major cause of aging and many age-related diseases including Alzheimer's disease. rheumatoid arthritis. cancer. and atherosclerosis. ONO-, a powerful oxidant, can cause damage of proteins, lipid and DNA through nitration and oxidation. (omitted)

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