Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Submicrosecond dynamics of nucleic acids studied with a long-lifetime metal-ligand complex

  • Kang, Jung-Sook (Dept. of Oral Biochem) ;
  • Son, Woo-Sung (Orthodontics. Col. of Dentistry Pusan Notational University) ;
  • Kostov-Yordan (Dept. of Chem ＆ Biochem. Eng., Univ. of Maryland Baltimore County)
  • Published : 2002.10.01
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Abstract

The metal-ligand complex, ［Ru(phen)$_2$(dppz)]^{2＋}$ (phen = 1.10-phenanthroline, dppz = dipyrido［3.2-a:2', 3'-c］phenazine) (RuPD), was used as a spectroscopic probe for studying nucleic acid dynamics. The RuPD complex displays a long lifetime and a molecular light switch property upon DNA binding due to shielding of its dppz ligand from water. (omitted)

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