Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Modulation of the activity of ex vivo cultured leukemic-DC by L-ascorbic acid (LAA)

  • Lee, Hyun-Ah (The Cancer Center, Div. Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University of Medicine) ;
  • Baek, So-Young (The Cancer Center, Div. Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University of Medicin) ;
  • Lee, Hong-Gi (The Cancer Center, Div. Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University of Medicin) ;
  • Kim, Ki-Hyun (The Cancer Center, Div. Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University of Medicin) ;
  • Park, Chan-Hyung (The Cancer Center, Div. Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University of Medicine)
  • Published : 2002.10.01
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Abstract

L -ascorbic acid (LAA) was shown to modulate the in vitro growth of leukemic-colony forming cells from patients with acute myelogeneous leukemia (AML). Dendritic cells (DCs) were successfully cultured from the leukemic blasts by us and others. The effects of LAA on the ex vivo cultured leukemic-DC were studied. Plastic adherent cells from the leukemic blasts were cultured with GM-CSF and IL -4 (each 103 U/$m\ell$) with or without LAA (300 ${\mu}$M) for 7 days and harvested. (omitted)

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