Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.301.2-301.2
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- 2002
Effect of Trolox C on CYP450 Isozymes Activity and Expression in Hepatic Ischemia/Reperfusion
- Eum, Hyun-Ae (College of Pharmacy. Sungkyunkwan University) ;
- Kim, Sung-Ho (College of Pharmacy. Sungkyunkwan University) ;
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Lee, Sun-Mee
(College of Pharmacy. Sungkyunkwan University)
- Published : 2002.10.01
Abstract
The present study was done to determine the effect of trolox C. a hydrophilic analogue of vitamin E. on alteration in cytochrome P-450 (CYP)-dependent drug metabolism during ischemia and reperfusion. Rats were subjected to 60 min of hepatic ischemia and 5 h of reperfusion. Rats were treated intravenously with trolox C (2.5 mg/kg) or vehicle (PBS. pH 7.4), 5 min before reperfusion. Serum alanine aminotransferase and lipid peroxidation levels were markedly increased after ischemia and reperfusion. This increase was significantly suppressed by trolox C. (omitted)
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