대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.297.3-298
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- 2002
Protective effect of KR-32000 against hypoxia- and oxidative stress-induced cardiac cell death
- Kim, Mi-Jeong (Department of Physiology, School of Medicine, Ajou University) ;
- Yoo, Sung-Eun (Bioorganic Division, Korea Research Institute of Chemical Technolog) ;
- Yi, Kiu-Yang (Bioorganic Division, Korea Research Institute of Chemical Technolog) ;
- Lee, Sun-Kyung (Bioorganic Division, Korea Research Institute of Chemical Technolog) ;
- Lee, Soo-Hwan (Department of Physiology, School of Medicine, Ajou University) ;
- Baik, Eun-Joo (Department of Physiology, School of Medicine, Ajou University) ;
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Moon, Chang-Hyun
(Department of Physiology, School of Medicine, Ajou University)
;
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Jung, Yi-Sook
(Department of Physiology, School of Medicine, Ajou University)
- 발행 : 2002.10.01
초록
A benzopyranyl derivative. KR32000. synthesized as a plausible KATP opener. has been shown to exert cardioprotective effect in vivo myocardial infarct model. In this study. we investigated whether KR32000 can produce cardioprotective effect against hypoxia- and reactive oxygen species(ROS)-induced injury in heart-derived H9c2 cells. Hypoxic injury was induced by incubating cells in anaerobic chamber (glucose-free. serum-free DMEM. 85% N2. 5% CO2. 10% H2) and oxidative stress was induced by buthionine sulfoximine(BSO). (omitted)
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