Histamine Releasing Factor (HRF) Evokes [3H] Dopamine Release by a Ca^{2+} - independent Pathway in Pheochromocytoma Cells

  • Seo, Ji-Hui (College of Pharmacy. Ewha Womans University) ;
  • Kim, Hwa-Jung (College of Pharmacy. Ewha Womans University)
  • Published : 2002.10.01

Abstract

The recombinant histamine-releasing factor (rHRF) has been reported to induce a secretion of histamine and cytokines from inflammation-related cell types such as basophils and eosinophils. and to function as a growth factor in immune B cells. Recently. decreased expression level of HRF protein was observed in brain of patients with Alzheimer disease and Downs syndrome. suggesting a possible significant role in neurological systems. (omitted)

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