대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Ircinin-1 from the Sponge Sarcotragus Species Induces of Cell Proliferation and Apoptosis in the Human Skin Cancer Cells

  • Choi, Hye-Joung (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Yee, Su-Bog (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Park, Hwa-Sun (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Chung, Sang-Woon (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Park, Sang-Eun (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Jung, Jee-Hyung (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Kim, Nam-Deuk (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center)
  • 발행 : 2002.10.01
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초록

We investigated the anti-proliferative effects of a new compound. ircinin-1. from the sponge Sarcotragus sp. on SK-MEL -2 human skin cancer cells. From the data of MTT assay, cell viability was decreased by ircinin-1 in a dose-dependent manner. We observed that the anti-proliferative effect of ircinin-1 was due to the induction of apoptosis, which was confirmed by observing the morphological changes. the increased ratio of pro-apoptotic protein Bax to anti-apoptotic protein Bcl-2, and cleavage of poly(ADP-ribose) polymerase protein, via activation of caspase-3. (omitted)

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