Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Evaluation of electroretinogram and retinal histopathology in rabbits administered DA-8159, a selective PDE 5 inhibitor

  • Kang, Kyung-Koo (Dong-A Phamaceutical Research Institute) ;
  • Ahn, Gook-Jun (Department of ophalmology, Chung-Ang University Medical School) ;
  • Sohn, Yong-Sung (Department of ophalmology, Chung-Ang University Medical School) ;
  • Shim, Hyun-Joo (Department of ophalmology, Chung-Ang University Medical School) ;
  • Ahn, Byung-Ok (Department of ophalmology, Chung-Ang University Medical School) ;
  • Kim, Won-Bae (Department of ophalmology, Chung-Ang University Medical School) ;
  • Cho, Ho-Kyun (Department of ophalmology, Chung-Ang University Medical School)
  • Published : 2002.10.01
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Abstract

DA-8159. a selective inhibitor of phosphodiesterase type 5 (PDE5: IC$\sub$50/ 5ng/$m\ell$). is being developed as a new treatment for erectile dysfunction. Since DA-8159 has been shown to inhibit PDE6 enzyme (IC$\sub$53ng/$m\ell$). we evaluated the effect of DA-8159 on electroretinogram (ERG) and retinal histopathology in rabbits. The effect of oral DA-8159 (5 to 30mg/kg) on ERG recordings was investigated at pre-treatment. 1 and 5 hrs after administration in rabbits. (omitted)

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