대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- Pages.249.2-250
- /
- 2002
TOLERANCE AND PHARMACOKINETICS OF SINGLE-DOSE DA-8159, A SELECTIVE PDE5 INHIBITOR, IN HEALTHY MALES
- Bahang , Mi-Young (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
- Kang, Kyung-Koo (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
-
Ahn, Byoung-Ok
(Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University)
;
- Shim, Hyun-Joo (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
- Kim, Soon-Hae (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
- Yoo, Moo-Hi (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
- Kim, Won-Bae (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University) ;
- Paick, Jae-Seung (Dong-A Pharmaceutical Research Institute, College of Medicine, Seoul National University)
- 발행 : 2002.10.01
초록
Tolerance and pharmacolinetics after single-dose administration of DA-8159, a new selective PDE5 inhibitor under phase 1 study, were examined in 42 healthy male volunteers in a six-period, double-blinded placebo-controlled study. Participants received single oral tablet of DA-8159 (12.5 to 300mg) or placebo. Adverse effects and pharmacokinetic parameters were monitored during experiments. DA-8159 was well tolerated and the frequency of adverse events was dose-related. (omitted)
키워드