Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effect of Synthetic Bile Acid Derivatives on the Cell Cycle Modulation of HT -29 Human Colon Cancer Cells

  • Park, Sang-Eun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yee, Su-Bog (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Choi , Hye-Joung (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Chung, Sang-Woon (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Park, Hwa-Sun (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University) ;
  • Yoo, Young-Hyun (Dept. of Anatomy and Cell Biology, Dong-A University College of Medicine and Institute of Medical Science) ;
  • Kim, Nam-Deuk (Dept. of Pharmacy, Research Institute of Genetic Engineering, Pusan National University)
  • Published : 2002.10.01
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Abstract

We studied the effects of ursodeoxycholic acid (UDCA) and its synthetic derivatives. HS-l030 and HS-1183. and chenodeoxycholic acid (CDCA) and its synthetic derivatives, HS-1199 and HS-1200. on the human colon adenocarcinoma cell line. HT -29 (p53 mutant type). The effects on cell viability and growth were assessed by MTT assay and cell growth study. While UDCA and CDCA exhibited no significant effect, their novel derivatives inhibited the proliferation of HT-29 cell line in a concentration- and time-dependent manners. (omitted)

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