Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.244.1-244.1
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- 2002
Growth inhibition and cell cycle phase-specific apoptosis induced by celecoxib in human NSCLC cells in vitro.
- Choi, Kang-Eun (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea) ;
- Kang, Jin-Hyoung (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea) ;
- Kuh, Hyo-Jeong (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea)
- Published : 2002.10.01
Abstract
Cyclooxygenase-2 ( COX-2 ) is an inducible enzyme which produces prostanoids by various stimuli. Overexpression of COX-2 in many tumor types indicates its association with tumor progression, which has been a promising target for chemoprevention and chemomodulation. We studied conc- and time-dependency of COX-2 inhibition, growth inhibition, and cell cycle arrest induced by celecoxib, a selective COX-2 inhibitor, in human non-small cell lung cancer (NSCLC) A549 cells. (omitted)
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