Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.243.1-243.1
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- 2002
Inhibitory effect of 2-amino-3-ethoxycarbonyl-1-methyl pyrolo (3,2-b) naphtho-4,9-dione on tumor cell invasion in human fibrosarcoma cells by downregulating matrix metalloproteinase-2 and 9
- Park, Hyen-Joo (College of Pharmacy, Ewha Womans University) ;
- Hwang, Hye-Jin (College of Pharmacy, Ewha Womans University) ;
- Lee, Hyun-Jung (College of Pharmacy, Ewha Womans University) ;
- Suh, Myung-Eun (College of Pharmacy, Ewha Womans University) ;
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Lee, Sang-Kook
(College of Pharmacy, Ewha Womans University)
- Published : 2002.10.01
Abstract
Matrix metalloproteinases (MMPs) play an important role in tumor invasion and metastasis by matrix degradation. To analyze the effect of 2-amino-3-ethoxycarbonyl-1-methyl pyrolo (3,2-b) naphtho-4,9-dione (compound 1) on the invasion or metastasis of cancer cells the expression of matrix metalloproteases (MMPs) was investigated in human fibrosarcoma HT 1080 cells by AT -PCR or gelatin zymographic methods. (omitted)
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