Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.236.1-236.1
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- 2002
Application of in situ gelling mucoadhesive delivery system for plasmid DNA as a macromolecule
- Park, Jeong-Sook (College of Pharmacy. Seoul National University) ;
- Oh, Yu-Kyoung (College of Medicine. Pochon CHA University) ;
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Kim, Chong-Kook
(College of Pharmacy. Seoul National University)
- Published : 2002.10.01
Abstract
Mucosal administration of drug or therapeutic gene is emerging as a new route of delivery for systemic and local therapeutics. Previously. in situ gelling system has been applied to chemical drug such as acetaminophen. insulin. prostaglandin E1. and clotrimazole. Plasmid DNA has not been delivered in form of in situ gelling vehicles. To improve the intranasal absorption of plasmid DNA. we designed delivery systems composed of provide of in 냐셔 gelling and mucoadhesive polymers. (omitted)
Keywords