대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.232.1-232.1
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- 2002
Synthesis of 14C-Radio Isotope Labeled Quinolone Intermediates
- Shin, Hyun-Il (Korea Radio Chemicals Center) ;
- Kim, Young-Seok (College of Pharmacy. SungKyunKwan University) ;
- Lee, Ki-Seung (College of Pharmacy. SungKyunKwan University) ;
- Song, Sung-Geun (College of Pharmacy. SungKyunKwan University) ;
- Ye, In-He (College of Pharmacy. SungKyunKwan University) ;
- Ham, Won-Hun (College of Pharmacy. SungKyunKwan University) ;
- Oh, Chang-Young (College of Pharmacy. SungKyunKwan University)
- 발행 : 2002.10.01
초록
Methods of 14C-radio isotope labeling of quinolone intermediates at four different sites are described. 14C-radio isotope labeled quinolone intermediates can be synthesized from 14C-1-malonic acid, 14C-2-malonic acid, 14C-benzene ring. and 14C-trimethyl orthoformate. The major site of 14C-radio isotope labeled quinolone intermediates is from 14C-2-malonic acid. We want to help customers to choose the best way for synthesis of 14C-radio isotope labeled quinolone derivatives. and give a general comprehension for 14C-radio isotope labeled pharmaceutical compounds. (omitted)
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