대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.230.2-231
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- 2002
GENISTEIN INHIBITS $NF-_kB-DEPENDENT$ COX-2 INDUCTION IN HUMAN BREAST EPITHELIAL CELLS BY MODULATING THE ACTIVATION OF TATA-BINDING PROTEIN
- Chung, Myung-Hoon (College of Pharmacy, Seoul National University) ;
- Kim, Jung-Hwan (College of Pharmacy, Seoul National University) ;
- Keum, Joo-Seob (School of Medicine, Sung Kyun-Kwan University) ;
- Lee, Seung-Sei (School of Medicine, Sung Kyun-Kwan University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- 발행 : 2002.10.01
초록
Genistein has been shown to possess chemopreventive potential. but its underlying molecular mechanisms are largely unclear. In the present study, we have investigated the effects of genistein on induction of cyclooxygenase-2 (COX-2) that plays an important role in the pathophysiology of carcinogenesis as well as in mediating inflammation. 12-Ο-Tetradecanoylphorbol-13-acetate(TPA) caused transient increases in cox-2 expression and prostaglandin E
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