Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.227.2-228
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- 2002
Antitumor activity of oxaliplatin, 5-FU and paclitaxel given alone and in combination with ZD1839 in human gastric carcinoma cells in vitro.
- Jang, Ji-Hyun (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea) ;
- Lee, Sang-Hak (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea) ;
- Kang, Jin-Hyoung (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea) ;
- Sun, Hee-Sik (The Catholic Univ of Korea) ;
- Kuh, Hyo-Jeong (Catholic Research Institutes of Medical Science, The Catholic Univ of Korea)
- Published : 2002.10.01
Abstract
ZD1839 is a new anticancer agent which selectively inhibits EGFR tyrosine kinase. Oxaliplatin (LOHP), 5-FU (FU), and paclitaxel (PTX) have shown to be highly active against the gastric carcinomas. and ZD1839 is considered as a good candidate for the treatment of gastric cancers when combined with cytotoxic agents. In this study, we evaluated the antitumor effects of these agents in SNU-l human gastric cancer cells either alone or when given as a doublet. (omitted)
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