Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Three-dimensional Pharmacophore Mapping of a Series of Isoxazolylpiperazine Inhibitors Selectively acting on the Dopamine D4 Receptor

  • Pae, Ae-Nim (Biochemicals Research Center, Korea Institute of Science and Technology) ;
  • Lee, In-Young (Biochemicals Research Center, Korea Institute of Science and Technolog) ;
  • Koh, Hun-Yeong (Biochemicals Research Center, Korea Institute of Science and Technology)
  • Published : 2002.10.01
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Abstract

The discovery of new ligands with affinity and selectivity for the dopamine $D_2$ receptor subtypes is an important area in medicinal chemistry. The distribution of the $D_2$ receptors in the limbic areas of brain suggests that these receptors may be particularly an attractive target for the design of potential selective antipsychotic drugs without causing extrapyramidal side effects. (omitted)

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