한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)

한국생물물리학회 (The Korean Biophysical Society)
권호 표지

Redox-Dependent Modulation of RsrA, an Anti-Sigma Factor Regulating Thioredoxin Operons in Streptomyces coelicolor

  • Bae, Jae-Bum (School of Biological Sciences, College of Natural Science, Seoul National University) ;
  • Park, Joo-Hong (School of Biological Sciences, College of Natural Science, Seoul National University) ;
  • Roe, Jung-Hye (School of Biological Sciences, College of Natural Science, Seoul National University)
  • 발행 : 2002.06.01
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초록

$\sigma$$\^$R/ is a sigma factor responsible for inducing the thioredoxin system in response to oxidative stress in Streptomyces coelicolor. RsrA, an anti-sigma factor, specifically binds to $\sigma$$\^$R/ and inhibits $\sigma$$\^$R/-directed transcription under reducing conditions. Exposure to H$_2$O$_2$ or thiol-specific oxidant diamide dissociates $\sigma$$\^$R/-RsrA complex. The redox-dependent regulation of $\sigma$$\^$R/-RsrA binding has been reported to involve thiol-disulfide exchange in RsrA, which contains 7 cysteines in 105 amino acid residues.(omitted)

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