Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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ATM-induced Radiosensitization in vitro and in vivo

  • Choi, E.K. (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Ahn, S.D. (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsa) ;
  • Rhee, Y.H. (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsa) ;
  • Chung, H.S. (Department of Microbiology, College of Medicine, Inha University) ;
  • Ha, S.W. (Department of Therapeutic Radiology, College of Medicine, Seoul National University) ;
  • Song, C.W. (Radiobiology Laboratory, Department of Therapeutic Radiology, University of Minnesota Medical Schoo) ;
  • Griffin, R.J. (Radiobiology Laboratory, Department of Therapeutic Radiology, University of Minnesota Medical Schoo) ;
  • Park, H.J. (Department of Microbiology, College of Medicine, Inha University)
  • Published : 2002.06.01
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Abstract

It has been known that ATM plays a central role in response of cells to ionizing radiation by enhancing DNA repair. We have investigated the feasibility of increasing radiosensitivity of tumor cells with the use of ATM inhibitors such as caffeine, pentoxifylline and wortmannin. Human colorecta1 cancer RKO.C cells and RKO-ATM cells (RKO cells overexpressing ATM) were used in the present study. (omitted)

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