한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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- Pages.15-15
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- 2002
Structural Studies on PDE and Inhibitor Complexes
- Lee, Jie-Oh (Dept. of Chemistry, Korea Advanced Institute of Science and Technology)
- 발행 : 2002.06.01
초록
Cyclic nucleotide phosphodiesterases (PDEs) regulate physiological processes by degrading ubiquitous intracellular second messengers, cAMP or cGMP. The first crystal structure of PDE4D catalytic domain and a bound inhibitor, zardaverine, was determined. Zardaverine binds to a highly conserved pocket that includes the catalytic metal binding site.(omitted)
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