Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2002.06b
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- Pages.15-15
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- 2002
Structural Studies on PDE and Inhibitor Complexes
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Lee, Jie-Oh
(Dept. of Chemistry, Korea Advanced Institute of Science and Technology)
- Published : 2002.06.01
Abstract
Cyclic nucleotide phosphodiesterases (PDEs) regulate physiological processes by degrading ubiquitous intracellular second messengers, cAMP or cGMP. The first crystal structure of PDE4D catalytic domain and a bound inhibitor, zardaverine, was determined. Zardaverine binds to a highly conserved pocket that includes the catalytic metal binding site.(omitted)
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