Proceedings of the Korean Society of Veterinary Pathology Conference (한국수의병리학회:학술대회논문집)

Korean Society of Veterinary Pathology (한국수의병리학회)
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Inflammatory Large Bowel Disease in BALB/cA-Hfh11nu Naturally Infected with Helicobacter hepaticus

  • Kim, Bang-Hyun (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Won, Young-Suk (Genetic Resources Center, Research Institute of Bioscience and Biotechnolog) ;
  • Lee, Chul-Ho (Genetic Resources Center, Research Institute of Bioscience and Biotechnolog) ;
  • Hyun, Byung-Hwa (Genetic Resources Center, Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Park, Yang-Kyu (Genetic Resources Center, Research Institute of Bioscience and Biotechnology)
  • Published : 2002.11.01
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Abstract

The slowly growing microaerophilic Helicobacter strains were isolated from the fecal pallets of 2 BALB/cA-Hfh11$\^$nu/ mice with rectal prolapse. The rectums of these mice protruded approximately 2 to 3 mm from the anus and varied in color from pale pink to deep red. Histopathologically, chronic proliferative colitis and proctitis were observed. The epithelium were hyperplastic and lymphocytes infiltrated markedly in mucosa and submucosa. Our isolated bactrial strains were characterized by morphological, physiological, molecular methods and special staining, and they were found to be Helicobacter hepaticus. We could not find any other pathogens from both mice. These results demonstrate that this organism may be a pathogen of the inflammatory large bowel disease in immunodeficent mice.

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