Enhancement of Growth Performance in Transgenic Rabbits with Overexpressing Growth Hormone Receptor and IGF-1 Receptor Genes

  • Chang, Suk-Min (Devision of Applied Biological Science, Sun Moon University) ;
  • Kim, Hyun-Ju (Devision of Applied Biological Science, Sun Moon University) ;
  • Kim, Jin-Young (Department of Animal Science and Technology, Seoul National University) ;
  • Park, Wha-Sik (Department of Clinical Pathology, Kim Cheon University) ;
  • Im, Kyung-Soon (Department of Animal Science and Technology, Seoul National University) ;
  • Dong IL Jin (Devision of Applied Biological Science, Sun Moon University)
  • 발행 : 2002.06.01

초록

Transgenic rabbits were produced by micoinjection of DNA containing metallothionein promoter ligated to growth hormone receptor (GHR) and IGF-l receptor (IGF-lR) genes. Founder transgenic rabbits transmitted transgenes into pups with Medelian ratio. The mRNA expression of transgenes using Northern blotting with probes of IGF-IR and GHR genes was checked in liver of transgenic rabbits. Transgenic rabbits with IGF-IR and GHR genes more expressed mRNA than control non-transgneic rabbits. (omitted)

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