한국동물번식학회:학술대회논문집 (Proceedings of the KSAR Conference)
- 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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- Pages.82-82
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- 2002
Gene Targeting of Low Density Lipoprotein(LDL) Receptor Related Protein 5(LRP5) Involved in the Wnt Signaling Pathway
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Jeong, Young-Hee
(Department of Animal Science, College of Agriculture and Life Science, Chonnam National University)
;
- Kim, Suck-Ho (Department of Animal Science, College of Agriculture and Life Science, Chonnam National University) ;
- Kim, Dong-Ho (Tohoku University Gene Research Cente) ;
- Moon, Seung-Ju (Department of Animal Science, College of Agriculture and Life Science, Chonnam National University) ;
- Tokuo Yamamoto (Tohoku University Gene Research Cente) ;
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Kang, Man-Jong
(Department of Animal Science, College of Agriculture and Life Science, Chonnam National University)
- 발행 : 2002.06.01
초록
The Wnt signaling pathway plays pivotal roles in embryonic development and oncogenesis through various signaling molecules inculding Frizzled receptor, recently characterized LRP5/6 and Dickkopf protein. Although Wnt signaling has been characterized in both developmental and oncogenic processes, little is known about its function in the normal adult. The ability of LRP5 to bind apolipoprotein E(apoE) and the abundant expression of LRP5 transcripts in hepatocytes, raise the possibility that LRP5 plays a role in the hepatic clearance of ApoE-containing chylomicron remonants, a major plasma lipoprotein carrying diet-derived cholesterol. (omitted)