한국동물번식학회:학술대회논문집 (Proceedings of the KSAR Conference)
- 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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- Pages.4-4
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- 2002
C-kit Expressing Male Germ Cells were Highly Sensitive to Busulfan Treatment and Apoptosis of Male Germ Cells Induced by Busulfan Treatment was not Caused by Fas/FalsL or p53
- Ok Do-Won (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University) ;
- Lee Mi-Suk (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University) ;
- Gwon Deuk-Nam (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University) ;
- Kim Jin-Hoe (Dept. of Dairy Science, Division of Applied Life Science, Gyeongsang National University)
- 발행 : 2002.06.01
초록
Male germ cell apoptosis has been extensively explored in rodent. In contrast, very little is known about their susceptibility to apoptosis stimuli of developing germ cell stages at the time when germ cell depletion after busulfan treatment occurs. Furthermore, it is still unanswered how spermatogonial stem cells are resistant to busulfan treatment. Spontaneous apoptosis of germ cells was observed in the testis of adult mice and experimentally induced busulfan treated mice increased this apoptosis to such an extent that there was a decrease in the weight of the testis. (omitted)