한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.196-196
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- 2002
SAFETY EVALUATION OF ADENOVIRUS-MEDIATED P16 GENE TRANSFER BY USING MICROARRAY AND 2D/MALDI-TOF
- Park, Misun (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Hoil Kang (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Jaehee Pyo (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Sinae Lim (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Seungwan Jee (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Miok Eom (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Taikyung Ryeom (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA) ;
- Kim, Okhee (Division of Genetic Toxicology, National Institute of Toxicological Research, KFDA)
- 발행 : 2002.11.01
초록
p16INK4a tumor suppressor gene transfer in the non-small cell lung cancer cells by transduction of recombinant adenovirus (Ad5CMV-p16) resulted in significant inhibition of cancer cell growth (Anticancer Res., 1998, 18:3257-3261). As a safety concern, we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) in human non-small cell lung cancer (A549) cells by using microarray and 2D gel electrophoresis/ MALDI-TOF.(omitted)