Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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CHANGES OF BLOOD PARAMETERS AFTER ESCALATING DOSE OF DA-3021 IN CYNOMOLGUS MONKEY

  • Kim, Choong-Yong (Non-human Primate Team, Toxicology Group, Korea Institute of Toxicology) ;
  • Heo, Jeong-Doo (Non-human Primate Team, Toxicology Group, Korea Institute of Toxicology) ;
  • Han, Su-Cheol (Non-human Primate Team, Toxicology Group, Korea Institute of Toxicology) ;
  • Jo, Yeong-Woo (Research Lab., Dong-A Pharm. Co., Ltd.) ;
  • Chung, Moon-Koo (Non-human Primate Team, Toxicology Group, Korea Institute of Toxicology)
  • Published : 2002.11.01
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Abstract

Interferon has therapeutic potential for a wide range of infectious and proliferous disorders such as chronic hepatitis C. However, it has drawbacks such as relatively short serum half-life and rapid clearance like other therapeutic proteins. The attachment of a polyethylene glycol (PEG) moiety to interferon is considered as one of the most promising solutions for its ability to extend the plasma residence time.(omitted)

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