Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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The induction of Micronucleus and Aneuploidy in human lymphocytes by Hydroquinone and its association with Genetic Polymorphisms of CYP1A1, GSTM1, GSTT1, NQO1 gene

  • Chung, Eun-Jung (School of Public Health, Seoul National University) ;
  • Kim, Tae-Yon (School of Public Health, Seoul National University) ;
  • Kim, Jin-Sik (School of Public Health, Seoul National University) ;
  • Kim, Yang-Ji (School of Public Health, Seoul National University) ;
  • Cho, Yoon-Hee (School of Public Health, Seoul National University) ;
  • Chung, Hai-Won (School of Public Health, Seoul National University)
  • Published : 2002.11.01
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Abstract

In order to investigate whether the induction of micronucleus and aneuploidy in human lymphocytes by Hydroquinone (HQ) is associated with genetic polymorphisms of CYP1A1, GSTM1, GSTT1, NQO1 gene, the cytokinesis-block micronucleus (CBMN) assay in combination with fluorescence in situ hybridization (FISH) technique using specific centromeric probes for chromosome 7 and 8 and PCR-RFLP based genotyping for 30 healthy people were performed.(omitted)

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