Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.11b
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- Pages.161-161
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- 2002
EFFECT OF PROLYL 4-HYDROXYLASE INHIBITOR HOE 077 AND ITS DERIVATIVES ON THE COLLAGEN SYNTHESIS IN HSC-T6 CELLS
- Joo, Yang-Hee (Graduate School of Biotechnology, Korea University) ;
- Jung, Seung-Hyun (Graduate School of Biotechnology, Korea University) ;
- Kim, Hyun-Jung (Graduate School of Biotechnology, Korea University) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
- Yi, Jung-Bum (Life Science Research Center, SK chemicals) ;
- Lee, Namkyu (Life Science Research Center, SK chemicals) ;
- Cho, Yong-Baik (Life Science Research Center, SK chemicals) ;
- Kwak, Wie-Jong (Life Science Research Center, SK chemicals) ;
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Dong, Mi-Sook
(Graduate School of Biotechnology, Korea University)
- Published : 2002.11.01
Abstract
The abnormal accumulation of collagen is progressive and often results in impairment of liver function, i.e. liver cirrhosis. Collagen synthesis requires several posttranslational events. Prolyl 4-hydroxylase is the key enzyme in collagen synthesis that catalyzes the hydroxylation of peptide-bound proline residues to 4-hydroxyroline.(omitted)