Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

13-weeks toxicity study of fructus of Aristolochiae contorta in SD rat

  • Hwang, Myung-Sil (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Park, Mi-Sun (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Moon, Gi-Young (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Lee, Ji-Sun (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Yum, Young-Na (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Cho, Dae-Hyun (Department of General Toxicology, Institute of National Toxicological Research) ;
  • Yang, Ki-Hwa (Department of General Toxicology, Institute of National Toxicological Research)
  • Published : 2002.11.01
Download PDF
⟨ Previous Next ⟩

Abstract

The potential toxicological effects of aristolochic acid (AA), a natural component in Aristolochiaceae family, were investigated. The 13-week toxicity study consisted of groups of 10 SD rat/sex administrated water containing 0, 0.05, 0.5, or 5 mg/kg per day AA (Study 1). The tested groups were terminated on Test Day 90 due to mortality and overt clinical signs of toxicity.(omitted)

Keywords