한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.142-142
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- 2002
INVOLVEMENT OF PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) PATHWAY IN H-RAS-INDUCED INVASION AND MOTILITY OF HUMAN BREAST EPITHELIAL CELLS
- Shin, Il-Chung (College of Pharmacy, Duksung Women′s University) ;
- Aree Moon (College of Pharmacy, Duksung Women′s University)
- 발행 : 2002.11.01
초록
Many studies have identified the phosphatidylinositol 3-kinase (PI3K) as a key regulator for various cellular functions including cell survival, growth and motility. We have previously shown that H-ras, but not N-ras, induces invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype.(omitted)