한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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- Pages.136-136
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- 2002
DOWN-REGULATION OF RAF-1 KINASE IS ASSOCIATED WITH PACLITAXEL RESISTANCE IN HUMAN BREAST CANCER MCF-7/ADR CELLS
- Lee, Michael (Korea Institute of Toxicology, KRICT) ;
- Jung Kwon (Korea Institute of Toxicology, KRICT) ;
- Wayne B. Anderson (Laboratory of Cellular Oncology, NCI, NIH, Bethesda) ;
- Chung, Moon-Koo (Korea Institute of Toxicology, KRICT)
- 발행 : 2002.11.01
초록
Experiments were carried out to determine the role of Raf-1 kinase in the development of drug resistance and apoptosis induced by paclitaxel. In the present study, paclitaxel sensitivity, Raf-1 activity and MAPKs activation were compared in 2 cell lines: parental human breast cancer cells and its drug resistant variant (MCF-7/Adr) cells.(omitted)